Toshikazu was Saito Tatsuoki cousin, head of Saitō clan.

In 1567, after the Battle of Inabayama, Toshikazu became a vassal of Akechi Mitsuhide, who was a retainer of the Oda clan.

Toshikazu became a commander of Akechi clan forces.

During the battle, he tried to flank Hideyoshi's lines but was defeated and executed by Horio Mosuke.

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