Saiyuki Reload began serialization in Ichijinsha's josei manga magazine Monthly Comic Zero Sum from March 2002 to June 2009, the chapters of which were collected and published in ten tankōbon volumes.

To stop the experiment Sanzo, Goku, Gojyo, and Hakkai head for Hoto Castle in Tenjiku Province.

Saiyuki Reload, written and illustrated by Kazuya Minekura, was serialized in Ichijinsha's josei manga magazine Monthly Comic Zero Sum.

[a] The series finished its final installment in the August 2009 issue of Monthly Comic Zero Sum, published on June 28, 2009.

Tokyopop's translation of Saiyuki GunLock was advertised on Geneon's DVD releases for the same series, and vice versa.

[48] Jarred Pine of Anime on DVD praised the first volume's packaging but criticized the story, stating: "Saiyuki Reload so far seems to have lost a lot of its charm and magic, relying much more on posing bishies and their oozing cool guy attitudes rather than crafting interesting stories to tell".

[49] Michael Deeley of Manga Life liked the premise and Art styles, liked how the art "switches from a realistic to cartoony style in the moment of action" and described the manga as "a good balance of action and drama" that is "bipolar, an action-comedy, one part and the other part is dark and dour".

[2] Publishers Weekly praised the protagonists, calling them likeable and enjoyable for new readers, stating: "with a winning combination of charming heroes, clever dialogue, great fight scenes and engaging stories, Reload is solid entertainment all the way".