It began serialization in Ichijinsha's josei manga magazine Monthly Comic Zero Sum since December 2009, with its chapters collected in three tankōbon volumes as of October 2017.

The story follows the adventures of The Sanzo Party after a long journey, as the group arrives at the borders of India, their final destination.

[14] Initially, the third volume was planned to be released in August 2017[15] but was postponed until October that year, when it was published alongside a special edition.

[56][57] Lastly, it secured the seventh spot on Kadokawa's eb-i Xpress website's poll of the top 20 "most anticipated summer 2017 Anime.

[59] Individual volumes have appeared in Oricon's weekly chart of best-selling anime DVD/blu-ray disc, taking several high spots.

[63][64] The fourth DVD volume of Saiyuki Reload Blast anime ranked third during the week of November 27 to December 3, 2017, selling 1,595 copies.

[68][69] Olivia Subero of Comic Book Resources noted that the series infuses historical anime with a supernatural twist.

[70] Gabriella Ekens of Anime News Network (ANN) found interest in the relationship between the characters and praised their story, describing it as serious with well-balanced character-based silly behavior, and becoming attached to them.

On the visual level, she called Saiyuki Reload Blast disappointing, noting the show's distinct art style, which is only rarely noticeably off-model.

[71] Fellow (ANN) reviewer Nick Creamer feels that Blast hits its targets perfectly and describes the character and background designs as "quite solid.

"[72] Another fellow (ANN) reviewer, James Beckett, describes the combination of the framework of traveling to the west with western styles as a more modern spaghetti, finding its purpose very interesting.

He concludes by saying, "This story did justice to the raw material and actually enhanced the characters, giving them deeper and more internal motivations for their actions, making their connection in their new life quite natural.