Saki's father listened to Western music of the 1970s and 1980s, but she did not fall in love with it herself until junior high, when she started playing classical and electric guitar.

[2] Although a member of the brass band since elementary school, a friend asked her to join the classical guitar club in junior high.

[3][4] In high school she was in a cover band named Kathy & Carol (キャシー＆キャロル), with whom she had her first live performance competing in a contest judged by Seikima-II guitarist Ace Shimizu.

[5][6][7] While majoring in Chinese at university, Saki made her professional debut in July 2010 as a member of the all-female rock trio Mixx alongside vocalist Asuka and drummer Jackson.

[6] Mary's Blood performed their first international show in Houston, Texas at Anime Matsuri 2013, and then signed to major record label Nippon Columbia for the release of their first album Countdown to Evolution on August 20, 2014.

[17][18] She also contributed guitar to the song "Frozen Rose" from the 2017 album Astraia by Yashiro, Mary's Blood's live support guitarist.

[19] After taking part in a similar performance at Naon no Yaon 2017, Saki organized the World Guitar Girls Collection project which features several female rock guitarists playing famous songs in instrumental medley format.

[21] Another performance took place at that year's Classic Rock Jam on November 25,[22] but the first standalone World Guitar Girls Collection concert was held on August 19, 2018.

[23][24][25] Saki met vocalist Mayu through a mutual friend and was part of a backing band that supported her at an August 2019 live session.

[26] After playing their first concerts on September 14 and 15 as part of Metal Weekend 2019 at Zepp Diver City, where they opened for Loudness and HammerFall, Nemophila released their first single "Oiran" on February 29, 2020.

[32] After two further studio albums, Seize the Fate (2022) and Evolve (2024), and a Nippon Budokan concert celebrating their fifth anniversary, it was announced that Saki had left Nemophila on March 31, 2024 due to "differences in direction".

"[5][36] Amahiru's self-titled debut album was released worldwide on November 27, 2020, and features British vocalist Archie Wilson, Dutch keyboardist Coen Janssen, and American drummer Mike Heller.

[35] Also in 2020, Saki took part in Shred Racers Online F2, an event produced by Young Guitar Magazine and Nippon Cultural Broadcasting to showcase technical guitarists.

[37] Saki began a solo career with the February 10, 2021, release of the instrumental "Brightness", which features Leclercq on bass, Epica keyboardist Coen Janssen, and drummer Shun Minari from Blindman.

[5] She described Mary's Blood as a straight heavy metal band, but because they have many different styles of songs, she feels free to make whatever sounds she wants with them.

The guitarist explained that Eye and Rio love visual kei music, which sometimes makes it difficult to find the tones to match the vocals.

[45] Saki described the music of Amahiru as more hard rock in comparison to Mary's Blood's straight heavy metal, and feels it should therefore be a "little more modern" and have less distortion.

[4][36] When she first joined Mary's Blood, she mainly used a KG-Fascist Grave Stone, a signature model of Seikima-II guitarist Luke Takamura that has a body sculpted to have a stone-like texture and a carving of a hand leaving scratch marks.

[4][45] It has Seymour Duncan pickups, a SH-10b-7 Full Shred in the front and a SH-8b-7 Invader in the back, and a "galaxy black" paint job with cherry blossom petals added because she wanted it to still be cute and "girlish".