Sakuma Nobumori (佐久間 信盛, also Dewa no Suke (出羽介) and Uemon no Jo (右衛門尉), 1528 – February 18, 1582) was a Samurai retainer of Oda Nobuhide.

In 1570, He was successful attacking Mitsukuri castle in the campaign against the Rokkaku clan and helped to suppress rebellions caused by Buddhist sects in Echizen Province.

His fellow commander Hirate Hirohide, however, who fought alongside the Tokugawa troops, lost his life, and the conflict ended with a crushing defeat of the Tokugawa-Oda alliance.

[3] In 1576, after Harada Naomasa's death during the campaign against the heavily fortified and well-supplied Honganji temple in Osaka, Sakuma was chosen as Harada's replacement as commander of the Siege of Ishiyama Hongan-ji and given troops from seven provinces placing him in command of the largest Oda-clan army among the Oda retainers.

However, unlike his colleagues Akechi Mitsuhide, Shibata Katsuie or Hashiba Hideyoshi who all won battles on the fronts to which they were assigned, Nobumori made no progress against the fearless Buddhist zealots.

Nobumori's banishment has widely been regarded as representative of Nobunaga's cold-blooded treatment against even his longest-serving retainers underscoring the clan leader's shortcomings as a military commander.