Sale Creek is an unincorporated community and census-designated place (CDP) in northern Hamilton County, Tennessee, United States.

A local curiosity, the reportedly "haunted" Shipley Hollow Road, is in Sale Creek.

The creek got its name from the auction held along its banks consisting of the goods and arms taken from the eleven towns of the militant Cherokee in the region before they were burned during the raid of Evan Shelby's troops in 1779 during the Cherokee–American wars.

[7] The area was occupied by the 6th Tennessee Infantry US from September to December 1863 during the Civil War.

Sale Creek is part of the Chattanooga, TN–GA Metropolitan Statistical Area.