As his parents did not have the money to educate all three of their sons, the elder two, John and Salentin, were chosen and sent to the cathedral of Mainz in 1548.
He did not have priestly consecrations as he intended to leave the church and take up rulership of the County of Isenburg-Grenzau in the foreseeable future, a condition which had the support of the cathedral chapter and the Holy Roman Emperor but not Pope Pius V, who demanded a new election was to take place.
However Pius V died in 1572 and his successor, Gregory XIII, confirmed the election the following year.
As the archbishop of Cologne, Salentin used its resources to improve the conditions in Isenburg-Grenzau, and succeeded in obtaining for it the status imperial immediacy in the Bench of Counts of the Wetterau.
[3] He had two sons, Salentin X and Ernest I and both, like their father, had successful military careers.