The current enrollment is about 930 students, declining from a peak of about 1,100 in recent years, from Delaware, Maryland, New Jersey, and Pennsylvania.

Salesianum has established a close connection with Lycée Saint Michel, another Oblate high school, located in Annecy, France.

[14] The cross country team has won 37 of the 42 DIAA state boys' championships, losing only five years between 1972 and 2013.

[17] In August 2012, the Wilmington/Philadelphia Province of the Oblates of St. Francis de Sales published a letter stating, "Since 2004, the Wilmington/Philadelphia Province of the Oblates of St. Francis de Sales has been named in lawsuits in the Superior Court of Delaware filed by 40 plaintiffs, each of which contained allegations of sexual abuse of a minor."

The letter named 12 oblates who had been involved and expressed regrets, stating, "The abuse of children by priests and other clergy is shocking, reprehensible, and devastating to all whose trust has been shattered by their selfish deeds.