St. Mary's Anglo-Indian Higher Secondary School is a Catholic higher secondary school for boys in Chennai, Tamil Nadu, India, operated by the Salesians of Don Bosco.

It is located on Armenian Street, Broadway opposite the High Court and adjacent to St Mary's Co-Cathedral.

It stands out today among the city schools for having often secured centum results in the Board Exams.

Saint Mary's Anglo Indian Higher Secondary School was founded in 1839 by Joseph Carew for the purpose of affording the Catholic youth of Madras an education.

The unit is attempting to procure a piece of land for the present pupils for games like volleyball and basketball.