The first Odstock Hospital was constructed in Britford parish in 1942 by the United States Army to treat American troops who were stationed in the Salisbury area during the Second World War.

[2] A spinal injuries treatment centre was officially opened by the Prince and Princess of Wales in 1984.

[3] In March 2018, retired Colonel Sergei Skripal (a former agent for Russia who then provided assistance to Britain and was caught and imprisoned by Russia and later freed in a spy swap), and his daughter, Yulia, were treated at Salisbury District Hospital after they were found poisoned by a substance thought to be a Novichok agent.

[4][5] In 2016 the hospital had over 4,000 members of staff and provided services to around 240,000 people in the counties of Wiltshire, Dorset and Hampshire.

[6] The Trust's arts department, ArtCare, was awarded a Heritage Lottery Fund grant in 2016[7] toward a two-year project to conserve and digitise the hospital's collection of historic material.