Located in the central part of the county along the Ohio River, it borders the following townships: Mason County, West Virginia lies across the Ohio River to the south.

It is the farthest downstream of Meigs County's Ohio River townships.

Two villages are located along Salisbury Township's shoreline: Middleport, the largest village in the county, in the southwest, and Pomeroy, the county seat, in the southeast.

[4] Located off State Route 124 near Rock Springs, the Meigs County Fairgrounds is listed on the National Register of Historic Places.

[5] The township is governed by a three-member board of trustees, who are elected in November of odd-numbered years to a four-year term beginning on the following January 1.