Artists such as Aurra,[1] Skyy, Double Exposure, Love Committee(Gold Mind),[2] Inner Life, Rafael Cameron,[3] Moment of Truth,[4] Jakky Boy & the Bad Bunch, Edwin Birdsong, Instant Funk, Loleatta Holloway, Civil Attack, First Choice, Joe Bataan, Vaughan Mason & Butch Dayo, Carol Williams, Jocelyn Brown, Ritchie Family, Salsoul Orchestra (led by Vincent Montana Jr) and Charo were at one time part of their roster.

[5][6] The Cayre family had been involved in many entrepreneurial ventures before they manufactured and distributed 8-track tapes, which included Bethlehem Records, in the early 1970s.

Bataan had the first single, "The Bottle", and album, Afro-filipino, on the initial Salsoul label released through Epic, before a deal with RCA.

Gamble and Huff were in dispute with their key musicians over business matters and Salsoul quickly took the chance to put them under contract.

Led by Rochelle Fleming, the group had success on the Philly Groove label with Armed and Extremely Dangerous (1973),[9] which Salsoul acquired and would re-release among its classic catalogue in the 1990s.

According to Ken Cayre, it was his exposure to early discothèques that gave him the idea to record music for the dance market.

It continued to release new material until 1984, when the Cayre brothers shut down their recorded music operations to concentrate on the home video business, such as GoodTimes Entertainment.

Because of the resurgent interest prompted by Loleatta Holloway's "Love Sensation", Black Box's "Ride on Time" & Marky Mark and the Funky Bunch's "Good Vibrations" in the late 1980s and early 1990s, the label's catalogue was digitally remastered.

In 1992 and 1993 Salsoul sub-label Double J released two volumes of remixes (Synergy and Rhythm) by contemporary house-music artists.