He had been training as an attacker for a local amateur side, Puri e Forti, at 11 years old when coaches concluded that his asthma condition would hinder him too much as an outfield player.

Following a string of unimpressive performances by Rubinho, Palermo coach Walter Zenga, himself a former goalkeeper who was noted for his ability, elevated Sirigu to the starting role for the Week 6 game, an away match against Davide Ballardini's Lazio on 27 September 2009.

Since then, Sirigu was regularly featured in the starting line-up and permanently confirmed as the first-choice goalkeeper, leading the club to send Rubinho out on loan to Livorno later in January.

[12] Although initially signed as a reserve for Nicolas Douchez, Sirigu started all 38 Ligue 1 matches during his first season at the club as PSG finished as runners-up to Montpellier HSC.

[17] On 2 August 2014, as PSG won the Trophée des Champions 2–0 against Guingamp at the Workers Stadium in Beijing, Sirigu saved a 32nd-minute penalty kick from Mustapha Yatabaré.

[20] After PSG completed the signing of German goalkeeper Kevin Trapp from Eintracht Frankfurt in July 2015,[21] deputy sporting director Olivier Letang announced that the club "would not stand in [Sirigu's] way" if he wished to leave Paris.

[24] On 12 February 2016, he announced that he would have left PSG during the previous winter transfer window if "an important proposal had arrived",[25] but ultimately remained with the club for the remainder of the season.

[28] Having made only three appearances for the Andalusians, Sirigu moved to fellow league club, strugglers CA Osasuna on 31 January 2017 for the remainder of the season.

[40] After playing two games – one in the UEFA Europa Conference League – he suffered an Achilles tendon injury in March, ruling him out for an estimated six months; his contract was set to expire in June, but included a one-year extension option.

[45] On 21 August 2007, he made his debut with the Italy U-21 squad under manager Pierluigi Casiraghi, in a 2–1 friendly victory against France held in La Spezia, coming on as a second-half substitute for Andrea Consigli.

[52] With Cesare Prandelli serving as national coach, Sirigu was named in his first squad list for the friendly match against Ivory Coast on 10 August 2010,[53] in which the goalkeeper also debuted as Italy lost 1–0.

[55] Sirigu was eventually selected to go to UEFA Euro 2012 as the third choice keeper of the Italian team, behind Gianluigi Buffon and Morgan De Sanctis;[56] he did not feature in the tournament as Italy reached the final, losing out 4–0 to Spain.

[66] Due to a fever suffered by starting goalkeeper Buffon, Sirigu made his only appearance of the tournament on 22 June, in his country's final group match, a 1–0 defeat to the Republic of Ireland.

[73] On 11 July, Sirigu won the European Championship with Italy following a 3–2 penalty shoot-out victory over England at Wembley Stadium in the final, after a 1–1 draw in extra-time.

[74] Sirigu was once again named Italy's second-choice goalkeeper for the 2021 UEFA Nations League Finals, where they finished in third place, beating out Belgium 2–1 in the bronze medal match.

[83] Sirigu is also known for his professionalism and leadership qualities, as well as his ability to motivate his teammates, and is therefore considered to be an influential dressing room personality, which makes him a popular figure with his teams' fans.