[2] Amo-Ameyaw joined Southampton from Tottenham Hotspur in August 2022 as a sixteen-year-old, having reportedly turned down the offer of a scholarship contract with Spurs.
[3] Compensation payments owed to Spurs by Southampton were reported to be close to a million pounds for Amo-Ameyaw and his teammate Jayden Meghoma, who made the same journey.
[6] Amo-Ameyaw made his Premier League debut on 28 May 2023 appearing as a second-half substitute for James Ward-Prowse as Southampton played a home match with Liverpool, which finished 4–4.
[7] At 16 years and 314 days, Amo-Ameyaw became the youngest-ever player to appear in the Premier League for Southampton.
[15] In November 2023, Amo-Ameyaw was named in the England squad for the 2023 FIFA U-17 World Cup and scored in their opening group stage game against New Caledonia.