She worked as a session backing vocalist, working with artists such as Gary Moore, George Harrison, Small Faces, Spandau Ballet, Adam Ant, Jon Lord (of Deep Purple), Pink Floyd, David Gilmour, The Firm, Dodgy and Nick Cave.

[2] Brown's first work in the music industry was in 1978 aged 14, when she sang backing vocals on the final studio album by the Small Faces, 78 in the Shade.

[2] She also worked as a backing vocalist with several other bands, including Spandau Ballet, and with her mother on former Deep Purple keyboardist Jon Lord's third solo album Before I Forget.

Brown's second studio album, April Moon (1990), included two hit singles, "Kissing Gate" and "With a Little Love".

[2] Brown, unwilling to compromise and after a protracted legal battle, bought back the master recordings of the album and released them in 1992 on her own label Pod Music, a year after the death of her mother.

[2] Her involvement was documented on the following year's Pink Floyd release, Pulse, in which she sang backing vocals and was the first lead vocalist on the song "The Great Gig in the Sky".

In 1997, Brown returned with her fourth studio album Box, released via the independent record label Demon Music Group.

In an interview in 2013 she explained that "I can't get vocal cord closure and achieve the proper pitch simultaneously.

[5][6][7] In 2021 she released her only live album, Wednesday The Something of April, a recording of a one-woman show from 2004 featuring songs from across her career.

It was written and recorded with long-time collaborator Danny Schogger and makes use of Melodyne software to help Brown's vocals.

She has worked with the band Barclay James Harvest (1984), David Gilmour (David Gilmour in Concert) and Pink Floyd, Deep Purple (In Concert with The London Symphony Orchestra), Jon Lord, The Firm, Gary Moore, George Harrison and Nick Cave.

In 2015, Brown started teaching backing vocals classes at the Academy of Contemporary Music (ACM) in Guildford, Surrey, a school for rock and pop musicians.