Samuel Harding Hairston (January 20, 1920 – October 31, 1997) was a Negro league baseball and Major League Baseball player.

He played for the Birmingham Black Barons and the Indianapolis Clowns of the Negro leagues and played part of one season with the Chicago White Sox as a catcher.

The five Hairstons who have played in the majors are tied for the most ever with the Delahanty brothers.

The two of the three other three-generation MLB families have four members each: the Boone family (Ray, Bob, Bret and Aaron) and the Bell family (Gus, Buddy, David, and Mike).

This biographical article relating to an American baseball catcher born in the 1920s is a stub.