She played Serena in the television series Hercules: The Legendary Journeys and hosts the weekday, syndicated radio program, The Sam Sorbo Show.

[1] Under her maiden name, Jenkins, Sorbo played Serena on the TV series Hercules: The Legendary Journeys.

[2] Sorbo starred as Dr. Caroline Eggert in the third season of Chicago Hope and alongside Steve Buscemi in Twenty Bucks and Ed and His Dead Mother.

She had guest appearances as Mariah on seaQuest DSV and she acted alongside her husband as Dr. Sara Riley, Dylan Hunt's former fiancee, in two episodes of Andromeda.

Sorbo has been a featured speaker on the ReAwaken America Tour, a series of events protesting COVID-19 mitigation measures and supporting Donald Trump's claims of a stolen election.