Samuel Thompson (May 27, 1908 – January 29, 1978), nicknamed "Sad Sam", was an American pitcher in the Negro leagues from 1932 to 1942.

A native of Sulligent, Alabama, Thompson attended Sumner High School and Wiley College.

[1] He pitched for over a decade in the Negro leagues, and was often ranked among the league's top hurlers.

[citation needed] Thompson died in Los Angeles, California in 1978 at age 69.

This Negro league baseball pitcher article is a stub.