As head coach, he led the Bengals to Super Bowl XXIII, which they lost to the 49ers 20–16, relinquishing the lead on a last-minute touchdown.

[2] Wyche also played for the Washington Redskins, Detroit Lions, St. Louis Cardinals, and Buffalo Bills.

[4] Wyche signed with the American Football League expansion Cincinnati Bengals for the 1968 season, when he started three games and also served as backup to John Stofa and Dewey Warren.

[5] Wyche continued to play for the Bengals as they entered the National Football League in 1970 as part of the NFL–AFL merger.

[8] In 1967, while at the University of South Carolina working on his MBA degree, Wyche was an assistant coach for the Gamecocks.

The NFL responded by changing the rules so that defenses could match the offensive substitutions before a snap was allowed.

[4] On December 10, 1989, during a game versus the Seattle Seahawks, Bengals fans began to throw snowballs onto the field in protest of what they believed to be a bad call by the officials.

The Seahawks, who were at their own 4-yard line and an easy target from the bleachers, refused to continue until the snowball-throwing stopped, and play was halted by the officials.

[4] During his Cincinnati tenure, Wyche also had an acrimonious relationship with Jerry Glanville, the head coach of the division rival Houston Oilers, whom he called a "phony"; the teams played each other twice each season.

[15] Near the end of his tenure with the Buccaneers, Wyche participated in a lighthearted pregame promotional piece for NFL Films.

At the time, Jimmy Johnson, then the recently dismissed coach of the Dallas Cowboys, was rumored to be heading to Tampa Bay to displace Wyche.

During the promo, Wyche was about to address his team when personnel assistant John Idzik ducked his head into the room.

Wyche disappeared, and in walked Johnson wearing a Buccaneers jacket, who then addressed "his" new team, to everyone's surprise.

[17] [18] In 1996, Wyche worked as a sports analyst with Marv Albert on a weekly NFL game for NBC.

Also in 2006, he began working with Tom Werme broadcasting Southern Conference Football for Fox Sports South.

His left Recurrent Laryngeal Nerve was severed during the procedure, leaving his voice consistently hoarse and scratchy.

[23] Wyche was diagnosed with melanoma in 2019 and died at his home in Pickens, South Carolina, on January 2, 2020, at the age of 74.

[25] Running as a member of the Republican Party, Wyche defeated Democrat Wesley Burbage for the Pickens seat, by a margin of 6,478 votes to 1,639.