She is best known for her films Dhayam, Bharateeyans and "Umran Ch Ki Rakheya".

[1] In 2023, Samaira Sandhu was nominated as Brand ambassador for "Nasha Mukt Bharat Abhiyaan", Chandigarh.

[2] In February 2024, Samaira Sandhu has been announced as State Icon for Lok Sabha elections 2024.

In the same year she has acted alongside Krushal Ahuja in a music album sung by Javed Ali.

[13][4] Samaira Sandhu wrote a book Heaven in a Hell which is based on drug addiction.