Samantha is an unincorporated community in Tuscaloosa County, Alabama, United States.

Samantha is located along U.S. Route 43, 14.8 miles (23.8 km) north of Tuscaloosa.

Samantha has a post office with ZIP code 35482.

[2][3] Samantha was named in honor of the wife of the first postmaster, Sylvester Monroe Cowden.

This Tuscaloosa County, Alabama state location article is a stub.