She is best known for portraying Barbara Windsor in the stage play Cleo, Camping, Emmanuelle and Dick and the television films Cor, Blimey!
: Murder Investigation Team, Melessa Tarly in the HBO series Game of Thrones, and Maureen Groff in Sex Education.
[3][4] Spiro decided to be an actress at the age of ten after seeing a production of Androcles and the Lion at the Open Air Theatre, Regent's Park.
[2] Spiro's first acting job after graduating from drama school was with the Open Air Theatre, Regent's Park, in productions of A Midsummer Night's Dream, The Boys From Syracuse and Macbeth.
[2] Her many theatre credits include As You Like It, Teechers, The Tragic Roundabout, Jumpers, On the Piste, Roots, How the Other Half Loves and Glyn and It, opposite Penelope Keith.
[8] Spiro played Barbara Windsor in Cleo, Camping, Emmanuelle and Dick at the National Theatre, a production she credits as her first big break, which "open[ed] a lot of doors".
"[5] Spiro reprised the role of Barbara Windsor in the television adaptation of Cleo, Camping, Emmanuelle and Dick, Cor, Blimey!, starring opposite Geoffrey Hutchings.
"[11] In order to research the part, Spiro spent time with a female Detective Inspector with the real-life Murder Investigation Team.
In 2012 she also appeared in the SkyArts comedy series Psychobitches, where she played various female icons including Audrey Hepburn, Elizabeth Taylor, Marilyn Monroe and Mary Whitehouse.
In September 2013, Spiro joined the cast of the BBC Three sitcom Bad Education as Professor Celia Green, the new deputy headmaster and adversary to Jack Whitehall's character.
[13] In 2018 Spiro played the role of Mrs Erlynne in Kathy Burke's production of Oscar Wilde's Lady Windermere's Fan at London's Vaudeville Theatre.
From 2019 to 2023, Spiro portrayed the recurring character Maureen Groff in Laurie Nunn's British comedy-drama series Sex Education.