[2][3] The series is set in the city of Mumbai and revolves around the lives of the residents of Gokuldham Co-operative Housing Society, who hail from different cultural and regional backgrounds.

Most story arcs depict either an individual, family, or maybe all of the residents of the Gokuldham Society getting into various kinds of problems and ultimately finding their way out.

[48] When the series completed 1,000 episodes on 6 November 2012,[49] Asit Kumarr Modi stated that it took eight years to get the show on air: "Originally, it was a column in a Gujarati magazine, and I bought its rights in 2001.

[57] Joshi and Vakani appeared as Jethalal and Daya in another SAB TV sitcom Sajan Re Jhoot Mat Bolo in 2010.

named "Mahasangam" aired in July 2014 in which CID visits Gokuldham Society to solve a murder mystery case.

[37] Sumeet Raghavan, Rupali Bhosale and Punit Talreja from Badi Doooor Se Aaye Hai appeared in an episode in 2015.

[62] In December 2021, cast of Taarak Mehta Ka Ooltah Chashmah appeared in Kaun Banega Crorepati.

[69] Taarak Mehta Ka Ooltah Chashmah is one of the longest-running television series in India and has gained a cult status over the years.

[71][72] In February 2015, Dilip Joshi, Disha Vakani, and Shailesh Lodha hosted the red carpet at the 60th Britannia Filmfare Awards to promote the Clean India campaign.

[75] Decoding the reason behind Taarak Mehta Ka Ooltah Chashmah's success, Yashika Singla of The Print stated, "The major appeal of the television show is the idea of ethics and 'Indian values' at the very core of its scripts.

[79] In May 2023, Monika Bhadoriya accused Asit Kumarr Modi and project head Sohail Ramani of encouraging a hostile workplace.

In an interview with Bombay Times, Palak stated that she had chosen to leave the show for professional growth and health reasons.

[82] In response, the production house issued a statement claiming that Palak had violated several important rules in her exclusive artiste agreement.

Palak, however, denied these allegations, asserting that she had informed the production house of her decision to quit well in advance and had followed the proper procedures.