The MRE comprises 21 municipalities in the Eindhoven agglomeration, with a total area of 1,457.81 square kilometres.

Final control over the MRE lies with the Regional Council (Dutch: Regioraad), which consists of representatives of the participating municipalities (either mayors or aldermen).

The Council sets the general parameters and long-term guidelines within which the MRE operates.

Being a city region, MRE is the concession granter for public transportation in the southeast of the province.

[4] The MRE also commissioned the creation of the Phileas, a guided bus which runs on the rapid transit lines to Meerhoven, Eindhoven Airport and Veldhoven.