[2] Prudhomme played as a goalkeeper for Reign FC, Washington Spirit, Houston Dash, and Boston Breakers in the National Women's Soccer League (NWSL).

During her two seasons with the Beavers, Prudhomme played a total of 31 matches, giving up 41 goals, producing 188 saves, and had a combined record of 11–15–5.

[16] Prudhomme didn't appear in any games for Houston in 2018 as Jane Campbell played every minute of the season in goal.

[17] Prudhomme was waived by the Houston Dash prior to the 2019 NWSL season so she could join the Washington Spirit preseason camp as a non-roster invitee.

[19] On July 15, 2019, Prudhomme was acquired by Reign FC in a trade with Washington Spirit in exchange for Elise Kellond-Knight.