Sir Sampson Darrell (1594 – 14 May 1635) was an English politician and Naval administrator who sat in the House of Commons from 1625 to 1626.
He was Surveyor of Marine Victuals of the Royal Navy from 1623 to 1635.
He matriculated at Queen's College, Oxford on 8 May 1607, aged 13 and was awarded BA on 31 January 1610.
In 1625, he was elected Member of Parliament for Wendover.
Darrell died in London at the age of about 39.