He partnered with Emanuel Bossart for the construction of an organ of 33 plays and 3 keyboards, intended for the Church of the Holy Spirit.
In 1726 (Nov 19th) Samson Scherrer married Verena Anna Edelmann, born about 1706 in Wildhaus, Canton St. Gallen.
He then moved to Geneva, where the use of the organ was still banned in Protestant churches, so therefore sought work in France, and particularly in the Dauphiné region.
[2][3] In 1753, Samson Scherrer returned to Geneva, where the organ was now permitted to be used and offered his services to the authorities who commissioned an instrument for St. Peter's Church.
Samson Scherrer died in Geneva on March 4, 1780, while still working on the organ at Nyon which was completed by his son Jean-Jacques and Nicolas and his companion Pierre Burkhard.