Samuel Caruthers (October 13, 1820 – July 20, 1860) was a U.S. Representative from Missouri.
Born in Madison County, Missouri, Caruthers graduated from Cumberland University, Lebanon, Tennessee.
He was admitted to the bar and commenced practice in Fredericktown, Missouri.
Congressman Caruthers held several local offices prior to being elected to the U.S. Congress.
He died in Cape Girardeau, Missouri, July 20, 1860.