Samuel Cohen (14 July 1812 – 4 November 1861) was a 19th-century Australian colonial politician and businessman.

Born at Lambeth, Surrey, of Jewish ancestry, to merchant Barnett Cohen (1779–1856) and his wife Sierlah née Levy (1788–1854), he emigrated to Australia, arriving in Sydney on 19 April 1834, aboard the Resource.

Cohen had been sent by his father to escort his brothers, David and Lewis, back to England, but was unsuccessful in doing so.

[2] In 1836 he co-founded a general merchants company with his brother David, operating out of Sydney and Newcastle in New South Wales.

The Empire reported that "the mournful cortege consisted of a hearse, fourteen mourning coaches, and seventy-two carriages... As the funeral passed through the different streets, large numbers of spectators assembled to witness it; thus showing the general esteem in which the deceased gentleman was held by all sections of the community.