Samuel Cupples (September 13, 1831 – January 6, 1912) was an American businessman and entrepreneur based in St. Louis, Missouri.

In 1888, he built his residential home on West Pine Boulevard, Cupples House, the cost totaling $500,000, which now would approximately equal $15 to 20 million dollars.

The home is now on the United States National Register of Historic Places and has been made into a museum located on the Saint Louis University campus, at 3671 West Pine Boulevard.

[2] Samuel Cupples married Margaret Amelia Kells on February 15, 1854, and had a child which died at birth.

Cupples, his daughter, Amelia Lowman Scudder, and Amelia's daughters Martha, Gladys and Maude, set out for a Mediterranean voyage with planned destinations of Jerusalem and the great pyramids of Egypt aboard the British ocean liner RMS Republic on January 22, 1909, in New York City.

The ship was in collision with a west-bound liner early the next morning in heavy fog, and sank.