During World War II, Briskin served in the army's Signal Corps as a film producer, attaining the rank of lieutenant colonel.

[10] The company's first film was The Truth About Women, a 1924 melodrama directed by Burton King, and starring Hope Hampton and Lowell Sherman.

[19] 1926 saw Briskin take a film crew on location to Sonora, Mexico, shooting for Whispering Canyon, starring Jane Novak and Robert Ellis.

[5] After Banner, Briskin returned to work at Columbia Pictures, where he began producing for them in 1926,[5] and in 1928 he was given control over 18 of their productions.

[29]In 1931 Harry Cohn became the first studio head to implement the new unit production system, wherein producers were given specific responsibility over individual films, rather than supervising dozens of pictures in a given year.

[45] In September 1935, after seven years, Briskin resigned from Columbia, failing to reach an agreement with Harry Cohn over stock options.

[46] For years, many in the film industry knew that Briskin was responsible for many of the successes at Columbia, even though studio head Harry Cohn was taking the credit.

[48] Shortly after that report, he was offered a front-office position at MGM, but turned it down because he wanted to be more actively involved in film production,[49] which was followed by a denial from Fox that he was headed to that studio.

Conflict was averted when Berman received a one-year extension on his contract, wherein he had sole authority over his productions, answering only directly to Kahane.

[58][59] Later that year, RKO gained the rights to the successful Irish play, The Plough and the Stars, by playwright Seán O'Casey.

[63] In September, Briskin was elected to the AMPAS board of governors, along with several others including Clark Gable, Darryl Zanuck, and Cecil B.

[64] The following month, Briskin initiated a policy wherein the younger players under contract to RKO could appear in stage productions in stock and little theater companies for short periods, in order for the actors to gain experience.

[65] Also in October, Briskin was chosen to succeed Louis B. Mayer as chairman of the motion picture community chest.

[73] During a strike by the Federated Motion Picture Crafts union in 1937, there was concern that they would be joined by members of the Screen Actors Guild.

[80] In mid-May, it was reported that Briskin was in negotiations with Sam Cohn to return to his former studio, Columbia, in the role of general manager.

Y. Frank Freeman, the associations chairman, appointed Briskin the chair of the committee on South American Film Facilities.

[98][99] After the attack on Pearl Harbor by the Japanese on December 7, 1941, there was concern that film professionals in Hollywood who were officers in the armed forces reserves might be called to active duty.

In that month, he and chair Nathan Levinson created a sub-committee in order to find more technicians to enlist in the Signal Corps.

[132] The studio's next film, State of the Union, starring Spencer Tracy and Katharine Hepburn, was scheduled to be distributed by MGM.

[134] The partners sought a major studio to buy Liberty Films before bank foreclosure, although Wyler and Stevens were "violently opposed" to the idea at first.

[143] After accepting the position, his tenure was short lived, as he resigned in January 1951, due to an undisclosed illness, although he remained employed by the studio.

[146] In July 1951 Briskin was selected to head up the "Movie Town U.S.A." radio advertising campaign for the Council of Motion Picture Companies (COMPO).

[147] The Movietime campaign was scheduled to debut on October 8, 1951, with over 200 acting stars and other Hollywood personalities volunteering their time to make personal appearances in all 48 of the U.S. State capitals,[148][149] although those locations were later changed to 33 major cities, due to a scheduling conflict with many of the state governors.

[150] In addition to his responsibilities at Paramount and with COMPO, in late 1951 Briskin partnered with Sol Lesser to produce 6 films, which were distributed by United Artists.

[5] In April 1958 Briskin resigned from MGM, in order to return to Columbia, this time as vice president in Charge of West Coast Activities.

Among the films scheduled for production during this span included Anatomy of a Murder, A Raisin in the Sun, and Suddenly, Last Summer.

[172] Shortly after, Briskin, reunited with his brother, announced that he was re-integrating Screen Gems back into Columbia, and it would no longer operate as a separate entity.

[174] In August, despite rising production costs, Briskin took the unprecedented step of lowering the fees Columbia charged independent producers under contract to the studio.

One of Briskin's children, Gerald (Jerry), also became a producer in the film industry, working at the same company as his father, Columbia.

Throughout his life Briskin was a well-known philanthropist, and was quite active in Temple Israel in Los Angeles, as well as Cedars-Sinai Hospital, where he served as president.