Samuel Jones Nicholls (May 7, 1885 – November 23, 1937) was a United States representative from South Carolina.

He served by special appointment as circuit judge and as associate justice of the Supreme Court of South Carolina.

He also organized and was captain for three years of Company I, First Regiment, South Carolina National Guard Infantry.

Nicholls was elected as a Democrat to the Sixty-fourth Congress to fill the vacancy caused by the resignation of Joseph T. Johnson.

He was reelected to the Sixty-fifth and Sixty-sixth Congresses and served from September 14, 1915 to March 3, 1921 and declined to be a candidate for renomination in 1920.