The group found modest success on Ghana's music scene from around 1959 with hi-life songs like "Obaa Kunadu", "Akwankwaa Hiani", "Kyere Me Ade a Meye", among others.
He founded the "SK Oppong Guitar Band" around the 1950s, composed of several accomplished musicians in the postcolonial era when "burger highlife" was beginning to gain popularity in Ghana.
Oppong found fame playing female roles in concert party, a stage production which combine drama and storytelling in a form of pantomime.
Oppong Guitar Band also took part in Jatokrom, a GTV Concert Party production which was managed by Nana Bosompra II.
Osofo Dadzie plays essentially translated popular Ghanaian oral narratives and everyday occurrences into dramatized performances.
Key themes of Osofo Dadzie plays were centred around the virtues of honesty, integrity, kindness, patience, forgiveness, endurance, modesty, unity, etc.
Some of his co-stars in the group include Nathaniel Frimpong Manso (Osofo Dadzie), Asonaba Kwaku Darko (Super OD), Kwadwo Kwakye, Fred Addai, Kingsley Kofi Kyeremanteng (Ajos), Mercy Offei, Bea Kissi, Jane Ackon (Mama Jane), Akua Boahemaa, Helena Maame Adjoa Pieterson (Adjoa Pee), Louisa Debra (Mama Lee) among others.
Ghana's Minister of Information and Presidential Affairs at the time, Mr Jake Obetsebi-Lamptey described SK Oppong as "a role model who educated Ghanaians through the arts.