Samuel Locke Sawyer (November 27, 1813 – March 29, 1890) was a U.S. Representative from Missouri.

He moved to Lexington, Missouri, in 1838 and continued his law practice.

Sawyer was elected judge of the twenty-fourth judicial circuit and served from 1871 until February 15, 1876, when he resigned.

He did not seek renomination in 1880, and returned to the practice of law and engaged in banking.

He died in Independence, Missouri, March 29, 1890, and was interred in Woodlawn Cemetery.