While studying, Samuel Masters was a preacher at Stanton Harcourt and South Leigh, both in Oxfordshire.

He was later made presbyter of St Paul's and Lichfield, and personal chaplain to the Earl of Radnor.

With an annual salary of £80 4d 4p, Masters occupied the position until his death in 1693, when he was replaced by Francis Atterbury.

In this period Masters, while moderate as a cleric, was an outspoken supporter of King William III's new regime, and published several works defending his leadership.

[6][7] In The Case of Allegiance in Our Present Circumstances (1689), Masters recounted that with the rule of James II he had lived under "a slavish fear" and that he had "almost lost [his] liberty of thinking freely.