The Samuel N. Patterson House is a historic residence in the city of Xenia, Ohio, United States.

Although he entered into partnership with another man, Tobias Drees, in the ownership of a local mill, he sought to make himself known as a carpenter.

Eventually, Patterson developed a strong reputation for his multiple artistic abilities, including wood carving.

Built of brick with a limestone foundation, the two-story house includes elements of stone and metal.

The Patterson House fared better than most; it was severely damaged, but the owner chose to restore it rather than completing the demolition.