After his marriage to poet Frances Sargent Locke, he continued his art education at the Royal Academy in London.
[1] Upon returning to America, he settled in New York City, where he was made an associate of the National Academy of Design.
In 1849, he went to California where he stayed nearly a year, prospecting for gold and painting portraits in San Francisco.
Osgood designed her memorial at Mount Auburn Cemetery in Cambridge, Massachusetts, where she was buried.
[2] His portrait sitters included his wife, Edgar Allan Poe, Davy Crockett, John Sutter, Henry Clay, Alice Cary, Mary Boykin Chesnut, Thomas Campbell, Mary E. Hewitt and Caroline E. S. Norton.