He totalled 170 games and three goals before a €25 million transfer to La Liga club Barcelona in 2016, winning three Copa del Rey and two league titles whilst a part of the side.

[8] He made his first appearance with the senior team on 16 August 2011, remaining an unused substitute as they defeated Rubin Kazan 3–1 in the first leg of the Champions League play-off round.

[9] He made his professional debut for the club on 8 January 2012, playing the whole match in a 3–1 victory over local rivals Lyon-Duchère in the Coupe de France.

[16] Umtiti picked up a knee injury in September 2016 while in Barcelona training, causing him to miss a crucial La Liga clash against Atlético Madrid.

[19] He would later play a vital role in the 2016–17 Champions League round of 16 second leg fixture against Paris Saint-Germain, as he started the match alongside Gerard Piqué and Javier Mascherano in a 3-man central defence partnership.

[20] He would cap off his first year in Spain by winning the 2016–17 Copa del Rey and by establishing himself firmly as first-choice in central defence for the club alongside Piqué.

[21] Now established as first-choice in defence at the club, after Barcelona's subpar 2017 Supercopa de España while reeling off the loss of Neymar, Umtiti began the season with great performances, under the guidance of new manager Ernesto Valverde.

[24] A week later, on 21 April, Umtiti started for Barcelona in the 2018 Copa del Rey Final, holding a clean sheet in an eventual 5–0 victory over Sevilla at the Metropolitano Stadium.

[25] Additionally, Umtiti won his first La Liga winners' medal during his second season in Spain, with the defender appearing in 40 games and scoring one goal across all competitions.

[21][28] In 2018, Umtiti picked up a knee injury which could have been treated with surgery, but he instead opted for conservative treatment, and proceeded to play in the 2018 World Cup, which he won with France.

[36][37][38][39] The Lazio fans involved kept targeting the two players with racist chants throughout most parts of the match,[36][37] with referee Livio Martinelli being forced to interrupt the game for a few minutes during the second half.

[47] Umtiti made his senior debut on 3 July by playing every minute of the quarter-final against Iceland at the Stade de France, replacing the suspended Adil Rami.

[54][55][56][57][58][59] In 2018, ESPN FC journalist Sam Marsden praised Umtiti's reading of the game, timing and risk-taking, adding that he could lead Barcelona's defence for the next five to 10 years.