[2][3] Initially a talented student athlete at Barcelona's La Masia academy, Piqué began his professional career with Manchester United in 2004.

[1] He started his career playing for FC Barcelona's youth teams as a defensive midfielder, but before he signed his first professional contract with the club, he decided to join Manchester United.

[6] Piqué made his debut for Manchester United in October 2004, as a centre-back, a 67th minute replacement for John O'Shea in a 3–0 League Cup victory at Crewe Alexandra.

His first league start came on 29 March 2006 against West Ham United at Old Trafford, playing at right-back, as Gary Neville was unavailable due to injury.

The terms of the loan required Piqué to feature in at least 20 games for the Aragonese club,[9] which he did, as he made 22 first team appearances in a successful spell, alongside Argentine Gabriel Milito, either as a centre-back or a defensive midfielder.

In his first start in the UEFA Champions League, a 4–0 home win against Dynamo Kyiv on 7 November 2007, Piqué scored the first of Manchester United's four goals in that match.

[15] He expressed his joy at re-signing with his boyhood club, although he admitted he had enjoyed his spell at Manchester United: I am very happy to be back, I didn't think I would be here again but this is very good for me.

To play with world class players has helped me and now I want to continue this at Barça.Piqué's first goal for Barcelona came in the club's 5–2 2008–09 UEFA Champions League group stage win at Sporting CP on 26 November.

[22] Three days later, Barcelona clinched the 2008–09 La Liga title after Real Madrid lost 3–2 to Villarreal, with two games left in the season.

[27][28] On 28 April, Piqué scored in Barcelona's 1–0 Champions League semi-final second leg victory against Inter Milan, though his team went out 3–2 on aggregate.

[35] Piqué, Xavi, Lionel Messi, Andrés Iniesta, Sergio Busquets, Dani Alves, and Pedro are the only players to have been a part of both treble-winning teams.

[46] In a 2–1 final win against Scotland, Piqué put in a strong performance in defence and also contributed in attack, hitting the crossbar with a header and providing the assist for striker Alberto Bueno to score Spain's second goal.

[47] Subsequently, he played in the 2007 FIFA U-20 World Cup, starting all six of Spain's matches and scoring a goal in the team's come-from-behind 4–2 victory over Brazil in the round of 16.

[51] In his second match as an international on 28 March 2009, he was called up as a replacement for injured teammate Carles Puyol and he scored the only goal in Spain's victory in the 2010 World Cup qualifier against Turkey at the Santiago Bernabéu Stadium in Madrid.

[53] Piqué made his tournament debut for Spain at the 2009 FIFA Confederations Cup, starting in four of the team's five matches as La Roja finished in third place.

[citation needed] Piqué was Spain's first-choice centre-back at the 2010 World Cup finals in South Africa, playing alongside Puyol.

[54] Piqué's partnership with Puyol saw Spain concede only twice in seven World Cup matches and keep four consecutive clean sheets in the knockout stage.

[58] In Spain's opening group game of UEFA Euro 2016 on 13 June, Piqué scored his fifth goal for his country, a late header in a 1–0 victory against the Czech Republic.

[6][63][64] He was also occasionally known to use his height as an additional attacking threat by advancing into more offensive positions, often functioning as an auxiliary striker, particularly if his team were trailing late on during matches.

[64][65][66] His ball-playing ability and capacity to read the game enabled him to form an effective central-defensive partnership with the more physical Carles Puyol, both with Barcelona and Spain.

), a sports and media investment group he founded with Hiroshi Mikitani (founder and chairman of Japanese e-commerce firm Rakuten, Inc.), Edmund Chu, Nullah Sarker, and Mike Evans.

[95] Piqué is the owner of Spanish second division football club FC Andorra, which he bought in December 2018 through his firm Kosmos Holding.

On 21 May 2022, the team was promoted to the Segunda División after beating already relegated UCAM Murcia 1–0 at home, thus ascending to the second tier for the first time in their history.

[102] On 10 July 2019, Piqué was ordered by a Spanish court to pay €2.1 million to the tax authorities following his conviction for image rights fraud.

He had been convicted by Spain's National Court in 2016 for faking the sale of his image rights to his Kerad Project company to evade taxes from 2008 to 2010.