As an academic magnet and college preparatory school, Wolfson specializes in Advanced Placement and International Baccalaureate courses.

Its name is derived from Samuel W. Wolfson, a local businessman whose family was prominent in Jacksonville, Wolfson houses the Finance, Law, and Business magnet program.

A VyStar Credit Union branch is located inside the school, and is available for students and faculty to use.

Wolfson is a member of the International Baccalaureate Diploma Programme.

Students represent many foreign countries including Bosnia and Herzegovina, Albania, and Lebanon, among others.