Samuel Webber (1759 – July 17, 1810) was an American Congregational clergyman, mathematician, academic, and the 13th president of Harvard University from 1806 until his death in 1810.

Webber was ordained as Congregational minister in 1787 and two years later became Hollis Professor of Mathematick and Natural Philosophy at Harvard.

[2] He served in the commission that drew the boundaries, later recognized by the Treaty of Paris, between the new United States of America and the surrounding British provinces.

[1] Webber's son, Samuel Jr., married Anna Winslow Green, a granddaughter of David Mathews, Loyalist Mayor of New York City under the British during the American Revolution.

Webber's son, also named Samuel (September 15, 1797 Cambridge, Massachusetts – December 5, 1880 Charlestown, New Hampshire), was a distinguished physician, chemist and author.