Samuel Wesley (10 February 1690 or 1691 – 6 November 1739) was a poet, teacher and an Anglican cleric.

He was the eldest of the Wesley brothers—with younger brothers John and Charles—but did not play a notable role in the nascent Methodist movement.

Wesley was educated at Westminster School before entering Christ Church, Oxford in 1711 where he received a B.A.

After that he was master of Blundell's School, Tiverton, Devon, where he died after a short illness on 6 November 1739.

A high church Tory, Wesley was a friend of Bishop Francis Atterbury.