Nearby barangays are Veterans Village (Project 7), Bahay Toro, Bungad, Katipunan, Del Monte and Paltok.

Founded by Saint Pedro Bautista on February 17, 1590, it was meant to be a place of solitude or "retreat" nestled atop a hill.

It was an independent town during the Spanish era with an area of 250 acres (1.0 km2) of land filled with wildlife and trees, later absorbed by Quezon City when it was created.

Today, it is a heavily populated industrial district with factories mostly located along Judge Juan Luna Street.

The patron saint of Barangay San Antonio is Anthony of Padua whose feast day, the entire community celebrates every 13 June.