On April 5, 1776, the de Anza Expedition called the area El Cañada de San Vicente as he traversed the west side of San Antonio Valley from north to south.

It was spelled San Antone on the 1924 "Mount Boardman, California" U.S. Geological Survey 15-minute quadrangle.

Arroyo Valle proceeds through Lake Del Valle to join Arroyo de la Laguna thence to Alameda Creek and finally terminates in San Francisco Bay.

[7] The area includes the San Antonio Valley Ecological Reserve, a 3,282 acre nature preserve created by a Nature Conservancy purchase of land from local rancher, Keith Hurner, and known for its herd of tule elk (Cervus canadensis nannodes).

[7][8] There is not historical evidence of San Antonio Creek, Beauregard Creek or Arroyo Bayo supporting steelhead trout (Oncorhynchus mykiss), although Arroyo Valle was a historical steelhead stream whose "headwaters were full of fish".