The area includes the San Antonio Valley Ecological Reserve, a 3,282-acre nature preserve created by a Nature Conservancy purchase of land from local rancher, Keith Hurner, and known for its herd of tule elk.

The Ohlone are speculated to have arrived in the Bay Area around 500 A.D. when they displaced Hokan speaking populations already in the region.

It was spelled San Antone on the 1924 "Mount Boardman, California" U.S. Geological Survey 15-minute quadrangle.

This restaurant serves as a community center as well as a stopping-off point for the many motorcycles, bicycles, and tourists that travel the roads.

Prior to this, a non-dial Western Electric 1A1 coin telephone served on San Antonio Road about one mile east of Lick Observatory.

The telephone utility serving this area today is Frontier Communications's Citizens Telecommunications Company of California.