It is found across from the church of Sant'Agata dei Goti on via Panisperna in the Rione Monti.

The church was built on the ruins of the monastery of Santa Veneranda.

The Baroque interior is elliptical in shape, and the cupola was frescoed by Bernardino Gagliardi with a Glory of San Bernardino and other Franciscan Saints.

Over the door to the sacristy is a canvas by Giovanni Baglione depicting Saints Francis, Clare, and Agatha.

Since 2003, the church has ministered to a Chinese catholic community in Rome.