San Bernardino Pass (Italian: Passo del San Bernardino, German: Bernhardinpass, 2,066 metres (6,778 ft)) is a high mountain pass in the Swiss Alps connecting the Hinterrhein and the Mesolcina (Misox) valleys between Thusis (canton of Graubünden) and Bellinzona (canton of Ticino).

Located in the far eastern side of the Western Alps it is not to be confused with the Great St Bernard Pass and the Little St Bernard Pass.

A road for wheeled vehicles was opened in 1770; this road was significantly improved between 1821 and 1823, financed in part by the Kingdom of Sardinia, keen to improve a trade route connecting Genoa and Piedmont to the Graubünden that was not directly controlled by Austria.

Traffic flow was much facilitated when in 1967, the San Bernardino road tunnel was completed: since then vehicle traffic on the pass has been reduced, benefiting those taking the time to avoid the tunnel.

The average climatic conditions for San Bernardino village at the entry point to the San Bernardino tunnel at 1,639 m (5,377 ft) are given in the following chart.