Near this site, prior to the devastating 1693 earthquake, was a small church titled Santa Maria della Dagala, belonging to a confraternity.
During the urban renewal following the earthquake, the confraternity of the Dagala church, joined with the local Camillian order, under the patronage of bishop Pietro Galleti, to build a new church dedicated to Saint Camillo de Lellis.
The initial design appears to have been by one of two Camillians, Domenico L Barbera or Vincenzo Caffarelli, but with contributions by Francesco Battaglia by 1735, but he is not associated with construction until 1771 until 1788.
The concave center is flanked by a fusion of corinthian pilasters.In the niche above the portal and a window, is the statue of St Camillo.
The interior houses a silver bust of St Camillus, and an altarpiece of the Ecstasy of San Camillo (1733) by Antonino Pennisi.