San Cosme is a station on Line 2 of the Mexico City Metro system.

[2][3] It is located in the Cuauhtémoc municipality of Mexico City, northwest of the city centre, on Avenue Ribera de San Cosme a few blocks before it becomes Calzada México-Tacuba.

The former name of the road was Calzada de San Cosme and a stream used to run along the way before the desiccation of Lake Texcoco, hence the name "ribera".

[2][5] The station pictogram depicts a balcony from the nearby colonial building known as La Casa de los Mascarones that currently houses the National Autonomous University of Mexico Foreign Languages School.

[2][3] The station was opened on 14 September 1970 as part of the second stretch of Line 2, from Pino Suárez to Tacuba.