San Domenico is a Gothic-style, Roman Catholic church located on via Berrettini in Cortona, region of Tuscany, Italy.
The unfinished grey stone brick facade with a peaked portal and a single small oculus leads into a well organized interior nave with elaborate side altars.
In the lunette over the doorway there is a fresco by Fra Angelico, depicting the Madonna and child with Saints Dominic and Peter Martyr.
The main altarpiece is a triptych by Lorenzo di Niccolò of Florence, depicting the Coronation of the Virgin, the Annunciation, the Crucifixion, and other scenes.
Epigraphs and signatures on the work document the painter and that it was donated in 1440 by Cosimo I de' Medici.